降钙素原监测对重症患儿抗菌药物应用的指导意义

Guiding significance of procalcitonin monitoring for antibacterial agents application in severe children

目的探讨降钙素原监测对于重症患儿抗菌药物临床应用的指导意义。方法 104例重症监护病房收治的患儿,根据就诊序号随机分成观察组(50例)与对照组(54例),对照组根据常规C-反应蛋白(CRP)、白细胞计数(WBC)、红细胞沉降率(ESR)等常规实验室检查结果进行抗菌药物选择,观察组在对照组检查项目基础上对降钙素原(PCT)情况进行监测,比较两组患儿的抗菌治疗疗程以及住院时间等情况。结果观察组患儿的抗菌治疗疗程及住院时间显著短于对照组,差异均具有统计学意义(P<0.05);观察组患儿各项临床实验室观察指标中除PCT治疗前后差异具有统计学意义(P<0.05)外,其余监测指标治疗前后差异均无统计学意义(P>0.05)。结论降钙素原可以灵敏反映重症患儿病情恢复情况,依据该监测治疗进行抗菌药物选择可有限缩短治疗疗程以及住院时间,在指导临床抗菌药物应用上具有积极临床意义。

Objective To investigate the guiding significance of procalcitonin monitoring for antibacterial agents application in severe children. Methods A total of 104 severe children were divided by their admission number into observation group （50 cases） and control group （54 cases）. Antibacterial agents for the control group were chosen according to conventional !aboratory test results of C-reactive protein （CRP）, white blood count （WBC）, and erythrocyte sedimentation rate （ESR）. The observation group received additional procalcitonin （PCT） monitoring on the basis of conventional test. Comparisons were made on antibiotic therapy course and hospitalization time between the two groups. Results The observation group had much shorter antibiotic therapy courses and hospitalization time than the control group, and the differences all had statistical significance （P〈0.05）. There was a statistically significant difference of PCT before and after treatment in the observation group （P〈0.05）, while the other indexes had no statistically significant differences before and after treatment （P〉0.05）. Conclusion Procalcitonin can sensitively reveal the recovery situation of severe children. Choice of antibacterial agents by monitoring treatment can shorten treatment coupe and hospitalization time, and it also provides positively clinical significance in guiding antibacterial agents usage.