中药分期论治联合米非司酮及氨甲蝶呤治疗异位妊娠的临床观察

Clinical observation on treatment of ectopic pregnancy by Traditional Chinese Medicine Treatment Based on Different Stages combined with Mifepristone and Methotrexate

目的:观察中药分期论治联合米非司酮及氨甲蝶呤对异位妊娠的临床疗效及对相关指标的影响。方法:收集2011年01月—2012年06月来自本院86例符合纳入标准的异位妊娠患者,随机分组,治疗组46例予中药分期论治联合氨甲蝶呤及米非司酮治疗,对照组40例予米非司酮及氨甲蝶呤。观察两组治疗前后血人绒毛膜促性腺激素(β-HCG)数值、包块大小、输卵管再通情况等指标的变化。结果:治疗组和对照组均可明显降低患者的血β-HCG水平,差异无显著性(P>0.05);治疗组能提高保守成功率,明显缩小异位妊娠包块大小,在改善患者的输卵管再通、减轻化疗药物副作用等方面疗效亦优于对照组(P<0.05)。结论:中药分期论治联合米非司酮及氨甲喋呤治疗异位妊娠,充分发挥了中西医结合治疗的优势,提高成功率,促进包块的消散,有利于输卵管再通、恢复功能,最大限度保留患者的生育能力。

Objective：To observe the efficacy and index of Traditional Chinese Medicine Treatment Based on Different Stages combined with Mifepristone and Methotrexate in the treatment of ectopic pregnancies. Methods：86 cases with ectopic pregnancy met the inclusion criteria From January, 2011 to June, 2012 in our hospital were randomly divided into two groups, the treatment group with 46 cases treated with Chinese medicine and staging treatment combined with mifepristone and methotrexate, the control group with 40 cases treated with mifepristone and methotrexate. The changes of blood beta-HCG numerical package block size, fallopian tube recanalization index of the two groups before and after treatment were observed. Results：The treatment group and the control group could significantly reduce serum-HCG level of patients without significant difference （P 〉 0.05）; the treatment group can improve the success rate of conservative, significantly reduce the ectopic pregnancy mass size, improve the tube recanalization and reduce chemotherapy side effects which were better than those of the control group with significant difference （P〈0.05）. Conclusion： Traditional Chinese Medicine Treatment Based on Different Stages combined with Mifepristone and Methotrexate give full play to the advantages of Integrated Chinese and Western medicine in the treatment of ectopic pregnancies, improving the success rate and promoting the package of block dissipation, which is conducive to the fallopian tube recanalization, the recovery of function and the maximization of the retention of patients with fertility.