观察乌司他丁治疗急性呼吸窘迫综合征的临床效果

Clinical effects of ulinastatin on treatment of acute respiratory distress syndrome

目的:观察乌司他丁对于急性呼吸窘迫综合征治疗的临床效果。方法:选取我院收治的44例急性呼吸窘迫综合征(ARDS)患者,随机分为观察组及对照组。对照组使用常规的治疗方法,观察组在此基础上加用乌司他丁治疗,观察对比两组患者的血气分析指标、白细胞计数,患者的住院时间、并发症发生率、病死率及疗效等情况。结果:所有患者的动脉血氧分压(Pa O2)及Pa O2/Fi O2均较治疗前显著升高,且观察组中的各项指标均比治疗前有明显的改善(P<0.05);治疗后观察组的Pa O2及Pa O2/Fi O2均较对照组高,且Pa CO2及WBC计数均较对照组低,P<0.05;观察组有效率明显高于对照组(86.36%VS 68.18%);观察组患者的呼吸机相关性肺炎(VAP)发生率、病死率均较对照组的要低,且住院时间也明显缩短,P<0.05,差异具有统计学意义。结论:在常规治疗基础上,结合使用乌司他丁,能显著改善ARDS患者的肺组织换气功能及预后。

Objective：To observe the clinical effect of ulinastatin on the treatment of acute respiratory distress syndrome. Methods：44 patients with ARDS were selected in our hospital and then divided into an observation group and a control group.The control group was given conventional treatment, while the observe group was given ulinastatin on the basis of therapy for the control group. the treatment of two groups of patients was observed and compared. Results：All patients with PaO2 and the PaO2/FiO2 was significantly ascended and all the indexes in observation group were improved than the prior treatment.PaO2 and PaO2/FiO2 in the observation group were ascended than the control group, and PaCO2 and WBC count in observation group were lower than that of the control group.The effective rate of the observation group were higher than that of control group（86.36%VS 68.18%）. The incidence rate and mortality rate of the observation group patients with ventilator-associated pneumonia （VAP） were higher than those of the control group to be low. P〈0.05, the difference is statistically significant. Conclusion：Conventional treatment combined with ulinastatin can significantly improve the lung ventilation function and prognosis of patients with ARDS.