RGS4在药物依赖受体信号通路中的调节作用

The regulation of RGS4 in receptor signaling pathwayof drug dependence

药物依赖形成机制复杂,涉及多脑区、多受体信号通路的共同调节。G蛋白信号调节因子4(RGS4)可通过作用于多巴胺、阿片、代谢型谷氨酸等受体系统参与药物依赖形成的调节。笔者以RGS4为靶点,通过对多巴胺、阿片、代谢型谷氨酸受体系统的影响阐述RGS4在药物依赖相关受体信号通路中的调节作用。

The formation mechanism of drug dependence is complex,involving the regulation of multiple brain regions and recep-tor signaling pathway.Regulator of G-protein signaling 4 （RGS4）could regulate the formation of drug dependence by acting on dopa-mine,opioid,metabotropic glutamate receptor system.This paper will expound the regulation of RGS4 inreceptor signaling pathwayof drug dependencevia the effects of dopamine、opioid、metabotropic glutamate receptor system with targetingas RGS4.