苯磺酸左旋氨氯地平联合依那普利治疗原发性高血压的疗效及安全性研究

Clinical efficacy and safety of levamlodipine besylate and enalapril in treatment of essential hypertension

目的探讨苯磺酸左旋氨氯地平联合依那普利治疗原发性高血压的疗效及安全性。方法选取2009年10月—2011年10月攀枝花市仁和区大河中路社区卫生服务中心收治的原发性高血压患者120例。根据高血压患者个体情况(年龄、身体状况、体质等)不同,采用适当剂量的苯磺酸左旋氨氯地平联合依那普利治疗。观察并记录所有患者治疗前及治疗2个月后血压控制情况,临床症状发生情况,心、脑、肾靶器官受损情况及心脑血管事件发生情况。结果血压控制总有效率为90.8%;患者临床症状完全消失87例(72.5%);治疗后患者头痛、乏力、头晕、眼花、耳鸣、注意力不集中、失眠发生率低于治疗前,差异均有统计学意义(P<0.05);靶器官损伤恢复率为61.5%;心脑血管事件发生率为2.5%。结论苯磺酸左旋氨氯地平联合依那普利治疗原发性高血压的疗效显著,可保护靶器官功能,且心脑血管事件发生率低,安全性高。

Objective To explore the clinical efficacy and safety of levamlodipine besylate and enalapril in treatment of essential hypertension. Methods A total of 120 patients with essential hypertension in Renhe River Road Community Health Service Center from October 2009 to October 2011 were selected. According to the individual of situation（ age,physical condition,physical）,they were given appropriate doses of levamlodipine besylate and enalapril. Before and 2 months after treatment,blood pressure,clinical symptoms,heart,brain and kidney target organ damage and cardiovascular events were observed. Results Total effective blood pressure control rate was 90. 8%. Patients with clinical symptoms disappear altogether had 87 cases（ 72. 5%）. After treatment,occurrence rate of headache,fatigue,dizziness,vertigo,tinnitus,inattention,insomnia incidence of patients were lower than before the treatment（ P 0. 05）. Target organ recovery rate was 61. 5%. The incidence of cardiovascular events was 2. 5%. Conclusion Levamlodipine besylate and enalapril has notable curative effect in the treatment of essential hypertension,can protect target organs function,has low incidence of cardiovascular events,and high safety.