帕罗西汀治疗脑卒中后抑郁症的临床疗效和安全性分析

Clinical efficacy and safety of paroxetine in the treatment of depression following stroke

目的探讨帕罗西汀治疗脑卒中后抑郁症的临床疗效和安全性。方法选取2010年9月—2012年3月于徐州市电力医院就诊的73例脑卒中后抑郁症患者,随机分为对照组34例和治疗组39例。对照组给予常规神经系统药物及对症支持治疗,治疗组在对照组基础上给予帕罗西汀治疗,比较两组患者的临床疗效及治疗前后的神经功能缺损(NIHSS)评分、抑郁自评量表(SDS)评分、生活质量评定量表(ADL)评分、汉密尔顿抑郁量表(HAMD)评分。结果治疗组总有效率(92.3%)高于对照组(70.6%),治疗后SDS、NIHSS、HAMD评分低于对照组,ADL评分高于对照组,躯体功能、生理功能、社会功能、物质生活得分均高于对照组,差异均有统计学意义(P<0.05)。结论帕罗西汀治疗脑卒中后抑郁症具有显著疗效,可明显改善患者焦虑、抑郁情绪,安全性高。

Objective To study the clinical efficacy and safety of paroxetine in the treatment of depression following stroke. Methods From September 2010 to March 2012 in Electric Power Hospital of Xuzhou City,a total of 73 depression following stroke patients were selected and randomly divided into control group（ n = 34） and treatment groups（ n = 39）. The control group received conventional nervous system drugs and symptomatic and supportive treatment,treatment group received paroxetine on the basis of control group,the clinical efficacy between the two groups were compared,before and after treatment the neurological defects（ NIHSS） score,Self-rating Depression Scale（ SDS） score, quality of life rating scale（ ADL）score,Hamilton Depression Rating Scale（ HAMD） score between the two groups were compared. Results The total effective rate of treatment group（ 92. 3%） was higher than control group（ 70. 6%）,after treatment SDS,NIHSS,HAMD scores were lower than the control group,ADL scores were higher than the control group,physical function,physiological function,social function,material life scores were higher than the control group,the differences were statistically significant（ P 0. 05）.Conclusion Paroxetine has significant effect in the treatment of depression following stroke,can significantly relieve the anxiety,depression,and has high safety.