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SB203580对大鼠高氧肺损伤后P38丝裂素活化蛋白激酶白细胞介素-8转化生长因子-β_1丙二醛含量变化的影响

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摘要 肺是氧化应激性损伤的重要靶器官。在高氧情况下,机体氧化/抗氧化系统易出现失衡,过多的氧自由基不仅可以直接或间接损伤肺组织细胞,而且可以通过细胞因子及炎症介质引起肺损伤,继而出现肺间质增生和纤维化,对新生儿而言,尚可引起支气管肺发育不良。目前,高氧肺损伤的发病机制尚不完全清楚。
作者 李双雪 王强
出处 《中国药物与临床》 CAS 2015年第3期347-349,共3页 Chinese Remedies & Clinics
基金 山西省卫生厅科技攻关项目(2011014)
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