莪术主要化学成分预防支架后再狭窄药理作用的研究进展

Advances in studies on pharmacological action of main chemical constituent of Curcuma Zedoary in preventing in-stent restenosis

中药莪术主要含挥发油、姜黄素等有效成分,具有抗血小板聚集、降血脂、抗氧化及抗炎等药理作用。近年来,研究表明莪术某些提取物和化学成分通过增强血管血红素氧合酶-1活性,缓解心肌细胞线粒体损伤以保护血管内皮;抑制核因子-κB(NF-κB)、靶基因白介素-受体相关激酶-1(IRAK-1)、肿瘤坏死因子受体相关因子-6(TRAF-6)和血管细胞黏附分子-1(VCAM-1)减少炎症浸润;且通过影向细胞磷酸酶氧化以抑制生长因子诱导的平滑肌细胞增殖及迁移等多重药理作用。因此,利用莪术对血管内皮细胞和平滑肌细胞的不同药理作用,应用于药物涂层支架,对预防支架后再狭窄和血栓形成可能具有潜在作用。该文就中药莪术提取物及主要化学成分,对预防支加内再狭窄的药理作用及机制研究作一综述。

Traditional Chinese medicine Curcuma Zedoary （E Zhu） contains essential oil, curcuminoid and other effective constituents, with such pharmacological actions as anti-platelet aggregation, lowing blood lipid, anti-oxidation and anti-inflammation. In recent years, studies have showed that certain extracts and chemical components of E Zhu could mitigate myocardial cell mitochondria injury and protect vascular endothelium by enhancing heme oxygenase-1 activity, inhibit nuclear factor NF-κB, target genes interleukin-associated kinase-1 （IRAK-1）, tumor necrosis factor receptor-6 （TRAF-6） and vascular cell adhesion molecule-1 （VCAM-1）, reduce inflammatory infiltration, and inhibit growth factor-induced smooth muscle cells （SMCs） proliferation and migration by impacting oxidation of cellular phosphatases. Due to its different functions in vascular endothelial cells and smooth muscle cells, E Zhu has been applied in drug-eluting stents, with a potential effect in preventing in-stent restenosis and thrombogenesis. In this paper, studies on pharmacological effects and mechanisms of extracts and main chemical constituents from E Zhu in preventing vascular restenosis were summarized.