基于肠道屏障的食物过敏机制研究进展

Advance in studies on food allergy mechanism based on gut barrier

食物过敏是对摄入食物蛋白的一种有害的免疫学反应,目前食物过敏已成为严重危害成人和儿童健康的公共卫生问题且发病率呈逐年上升的趋势,但目前针对食物过敏尚无有效的治疗方法,多采用规避过敏原及对症治疗。大量研究发现食物过敏性疾病的发生与肠道屏障功能损伤有关,在食物过敏患者中肠道通透性显著增加。因此,该文就近年来食物过敏与肠道屏障功能的相关性研究,食物过敏中肠道屏障损伤机制研究,以及基于肠道屏障功能的食物过敏干预策略研究进行了综述,以期为食物过敏性疾病的实验室研究和临床治疗提供参考。

Food allergies, as a type of adverse immune-mediated reactions to ingested food proteins, have become a serious public health issue that harms children and adults health, with increasing incidence year by year. However, without effective therapy for food allergies, doctors have mostly advised to avoid allergens and provided symptomatic treatment. According to the findings of many studies, allergic diseases are correlated with intestinal barrier function injury, as evidenced by the significant increase in the intestinal permeability among patients with food allergies. In this paper, recent studies on correlations between food allergies and intestinal barrier functions, intestinal barrier function injury mechanisms of allergic foods and food allergy intervention strategies based on intestinal barrier functions were summarized to provide reference for laboratory researches and clinical treatment of food allergic diseases.