环孢素A联合地尔硫卓引起嘴唇水肿、呕吐1例

One case of lip edema and vomiting caused by cyclosporine A combination with diltiazem

1例15岁男性患者因反复浮肿伴皮疹住院,既往有狼疮肾炎2年余。入院前使用激素和吗替麦考酚酯治疗,狼疮肾炎控制效果不佳,不良反应明显。入院后停用激素,改用环孢素联合地尔硫卓治疗,患者出现嘴唇水肿、呕吐、发热等不良反应。停用两药后对症治疗,明显好转,5 d后恢复正常,1周后给予他克莫司胶囊未出现类似症状。

One 15-year-old male patient with recurrent rash and swelling was admitted in hospital, with a history of lupus nephritis for more than 2 years. Glucocorticoids and mycophenolate mofetil were given before admission, lupus nephritis was not controlled well and adverse reactions happened. Steroid was replaced by cyclosporine and diltiazem after admission. Lip edema, vomiting and fever appeared and these two drugs were discontinued. The symptom signiifcantly improved after symptomatic treatment. Five days later, situation returned to normal. A week later, tacrolimus capsules were administrated and no similar symptoms occurred.