系统性红斑狼疮患者血脂异常相关性分析

Analysis of Correlation between Systemic Lupus Erythematosus Patients with Dyslipidemia

目的:探究系统性红斑狼疮(Systemic Lupus Erythematosu,SLE)患者血脂异常的相关性。方法:选取148例SLE患者作为观察组,选取同期50例健康体检者作为对照组,观察比较两组患者血脂水平,包括总胆固醇(TC)、高密度脂蛋白-胆固醇(HDL-C)、甘油三酯(TG)以及低密度脂蛋白-胆固醇(LDL-C)等。按照是否使用激素分为使用激素组(57例)和未使用激素组(91例),根据狼疮肾炎(LN)诊断标准分为LN组(69例)与非LN组(79例),比较使用激素者和未使用激素者、LN组和非LN组患者血脂水平。结果:SLE患者TC、TG及LDL-C水平均显著高于对照组,而HDL-C水平低于对照组。使用激素组患者TC、TG水平均高于未使用激素组,且HDL-C水平更低,差异具有统计学意义(P<0.05),但组间LDL-C水平比较差异无统计学意义(P>0.05)。结论:SLE患者血脂水平出现明显异常,较健康者更易发生粥样硬化,且长时间使用激素者与LN患者出现血脂异常的概率更高,因此SLE的血脂异常现象与使用激素、LN呈正相关。

Objective：To explore the systemic lupus erythematosus（systemic lupus erythematosu,SLE）patient correlation analysis of dyslipidemia.Methods：148cases of SLE patients as the observation group,remember.Then selected the same period of 50 cases of healthy people were used as control group.Observation on blood lipid levels in the two groups included the total cholesterol（TC）,triglyceride（TG）,high density lipoprotein cholesterol（HDL-C）and low density lipoprotein cholesterol（LDL-C）etc.The use of hormone and comparison of 148 cases of SLE patients and was not used hormone,lupus nephritis（LN）group and non LN group,serum lipid levels.Results：The patients with SLE TC,TG and LDL-C levels were significantly higher than those in the control group,while the HDL-C level was lower than that of control group.The use of hormone in blood lipid group and the LN group showed more obvious abnormal condition.Conclusion：SLE patients will appear obvious abnormal lipid levels,more easily than healthy atherosclerosis.And the long time use of hormone and LN patients with abnormal blood lipid,therefore,SLE will not abnormal blood lipid and hormone use,LN is positive correlation.