细菌耐药性检测方法的研究进展

Advances in detection of bacterial drug resistance

明确致病菌的耐药特性是指导各种细菌感染性疾病治疗的关键。常规药敏试验需要从标本中分离出菌株,操作烦琐、费时。近年来,一些分子生物学技术在细菌耐药性检测领域取得了很大进步,但临床应用方面还有待改善。本文重点介绍几种技术在细菌耐药性检测中的新进展,为临床实现细菌耐药性的快速准确检测提供参考。

The detection of bacterial drug resistance is essential for guiding the treatment of many types of bacterial infections. The most commonly employed method is antimicrobial susceptibility testing. This method requires that the pathogens are isolated from the clinical samples before testing, and it is complicated and also takes time. In recent years, some molecular biology techniques have made great progress in the detection of bacterial drug resistance, but still need to be improved in clinical practice. This paper aims to highlight several techniques and provide references for rapid pathogen resistance detecting in clinical practice.