联合检测血清降钙素原与C反应蛋白水平在感染性疾病中的价值

Detection Value of Serum Procalcitonin Combined with C-Reactive Protein in Infectious Diseases

目的评估联合检测血清降钙素原(PCT)与C反应蛋白(CRP)在感染性疾病中的价值。方法选取2013年10月至2014年10月我院收治的感染性疾病患者200例为研究对象,按照疾病种类分为病毒感染组和细菌感染组,每组各100例。测定并比较两组患者血清中的PCT和CRP水平。结果细菌感染组的PCT和CRP水平分别为(4.06±0.67)ng/L、(30.28±6.23)mg/L,均明显高于病毒感染组,差异有统计学意义(P<0.01)。细菌感染组的PCT和CRP阳性率分别为93.0%、72.0%,均显著高于病毒感染组的15.0%和41.0%,差异有统计学意义(P<0.01)。CRP、PCT对细菌感染的诊断敏感性分别为72.0%和93.0%,特异度分别为59.0%和85.0%。结论血清PCT作为感染标志物较CRP更敏感、特异度更高,可用于鉴别诊断感染性疾病细菌感染与病毒感染,二者联合检测可提高其敏感性和特异度,能为鉴别诊断细菌感染与病毒感染提供更可靠指标。

Objective To evaluate the detection value of serum procalcitonin （PCT） level and C-reactive protein （CRP） level in infectious diseases. Methods 200 patients with infectious diseases admitted to our hospital from October 2013 to October 2014 were selected and divided into bacterial infection group and viral infection group according to the type of disease, with 100 cases in each group. The levels of serum PCT and CRP were compared. Results The PCT and CRP levels of bacterial infection group were （4.06±0.67） ng/L and （30.28±6.23） mg/L respectively, higher than viral infection group, with statistical difference （P〈0.01）. The positive rate of PCT and CRP of bacterial infection group were 93.0%and 72.0%respectively, higher than 15.0%and 41.0%of viral infection group, with statistical difference （P〈0.01）. The sensitivity of CRP and PCT were 72.0%and 93.0%respectively, the specificity of CRP and PCT were 59.0%and 85.0%respectively. Conclusions Serum PCT has higher sensitivity and specificity than CRP as infection marker, which can be used for identifying and diagnosing the bacterial infections and viral infections. The combined detection of PCT and CRP can improve the sensitivity and specificity, and can provide a more reliable indicator for identifying and diagnosing the bacterial infections and viral infections.