眼内注射雷珠单克隆抗体对年龄相关性黄斑变性视网膜血管及视力恢复的影响

Effects of Ranibizumab on Fluorescein Angiographic Findings and Visual Acuity Recovery in Age-Related Macular Degeneration

目的:探讨眼内注射雷珠单克隆抗体对年龄相关性黄斑变性(age-related macular degeneration,AMD)患者的视网膜血管及视力恢复的影响。方法:选取47名AMD患者,共53只眼。比较治疗前后最佳矫正视力、黄斑中心厚度、视网膜动脉直径、视网膜静脉直径的变化,并将治疗后视力明显提高者纳入A组,而视力提高不明显或者恶化者纳入B组。比较两组治疗前后各参数的差异。结果:治疗后两组视网膜动脉直径均减小(P=0.007),黄斑中心厚度减小(P<0.001)。两组治疗前视网膜动脉直径(P=0.017)、视网膜静脉直径(P=0.001)、黄斑中心厚度(P=0.039)、平均最佳矫正视力(P=0.00)的组间差异均有统计学意义。结论:应用雷珠单克隆抗体治疗AMD能够使视网膜小动脉收缩,降低黄斑中心厚度,促进视力恢复。

Objective：To evaluate the effect of ranibizumab on retinal vessels and visual acuity（VA）in patients with age-related macular degeneration（AMD）.Methods：This study included 53 eyes of 47 patients.The study parameters were best-corrected visual acuity（BCVA）,central macular thickness（CMT）,diameter of retinal arteriole（DRA）,and diameter of retinal vein（DRV）.Eyes were divided into two groups according to VA recovery.Group A included cases showing significant recovery of VA,and Group B included cases showing preservation of VA or deterioration of VA.The related parameters were compared between the two groups.Results：There was a significant reduction in DRA（P =0.007）and CMT levels（P〈0.001）in both groups after treatment.When the two groups were compared,the differences in pretreatment values of DRA（P=0.017）,DRV（P=0.001）,CMT（P=0.039）,and mean BCVA（P=0.00）were statistically significant.Conclusions：Ranibizumab treatment can promote VA recovery.