阿德福韦酯联合拉米夫定治疗慢性乙型肝炎的临床疗效

Analysis of Adefovir Dipivoxil Combined with Lamivudine in Treating chronic Hepatitis B effect

目的探讨阿德福韦酯联合拉米夫定治疗慢性乙型肝炎的临床疗效。方法收集我院收治的54例慢性乙型肝炎患者资料,将患者随机分为治疗组(给予拉米夫定治疗)和对照组(给予拉米夫定联合阿德福韦酯治疗),均为27例,比较两组患者的临床治疗效果。结果对两组患者治疗后丙氨酸转氨酶(ALT)复常率、乙肝病毒变异株蛋白(YMDD)异常率、乙肝病毒脱氧核糖核酸(HBV-DNA)转阴率和乙型肝炎e抗原(HBe Ag)转阴率进行比较,治疗组患者各指标均优于对照组,差异有统计学意义(P<0.05)。结论阿德福韦酯联合拉米夫定治疗慢性乙型肝炎临床疗效较为理想。

Objective To analyze the adefovir and lamivudine in treatment of chronic hepatitis B effect.Methods Colected in our hospital 54 patients with chronic hepatitis B data,and randomly divided into treatment group（given lamivudine） and control group（given lamivudine combined with adefovir dipivoxil）,al 27 cases clinical treatment of patients were compared.Results After treatment of alanine aminotransferase（ALT）normalization rates of hepatitis B virus mutant protein（YMDD）anomalies rate of hepatitis B virus DNA（HBV-DNA）and hepatitis E antigen negative rate（HBeAg）seroconversion rates were compared in patients treated with the index than the control group,the difference was statisticaly significant（P〈0.05）.Conclusion Adefovir combined with lamivudine treatment of chronic hepatitis B clinical effect is better.