37例库肯勃瘤分析及女性激素受体研究

A Study of 37 Cases of Krukenberg Tumor and Female Hormone Receptors

应用免疫组织化学酶联亲和一步法标记库肯勃瘤组织中的雌激素受体（ＥＲ）和孕激素受体（ＰＲ）。结果表明：胃源性库肯勃瘤ＥＲ阳性率（６０％）明显高于大肠源性库肯勃瘤（２３．５％），统计学上有显著性意义（Ｐ＜０．０１）。胃癌比大肠癌更易转移到卵巢，胃源性库肯勃瘤生存期较大肠源性生存期要短。提出对双侧卵巢肿瘤患者应仔细对胃肠道等其它部位进行检查，以达到术前确诊，且对ＥＲ、ＰＲ阳性患者给予内分泌治疗，以求改善预后。

strogen and progesteron receptors(ER and PR) in Krukenberg tumor were studied using immunohistochemical enzymelinking affinity onestep method.The result showed that the positive rate of ER in gastrogenic Krukenberg tumor (60%) was higher than that in Krukenberg tumor of colonic origin (23.5%) .There was statistical significance (P<001).Gastric cancer metastasizes more easily to ovary than cancer of large intestinedoes.The survival time of gastrogenic Krukenberg tumor was shorter than that of colonic origin.It is suggested that the gastrointestinal tract and other parts of patients suffering from bilateral ovarian tumor should be examined in order to make diagnosis, and that endocrine therapy should be used in positive cases of ER and PR to promote prophylaxis.