苯并咪唑衍生物抗菌活性研究

Antibacterial activity of benzimidazole derivatives

以15种苯并咪唑衍生物为抑菌实验测试药品,以大肠杆菌、金色葡萄糖球菌等10种细菌作为受试菌种,通过平板法定性测定样品的抗菌活性。结果表明,除丁二苯并咪唑外,其他的化合物都表现出一定的抑菌活性。同时通过试管法定量测定了样品的最小抑菌浓度(MIC),实验结果表明,化合物对细菌都有较好的抑菌活性,其中2-(2-(1H-benzo[d]imidazol-2-yl)pyridin-3-yl)-1H-benzo[d]imidazole、2,3-吡啶二羧酸、1,2-di(1H-benzo[d]imidazol-2-yl)ethane-1,2-diol、2-phenyl-1H-benzo[d]imidazole具有广谱的抑菌活性,2,2’-联咪唑对枯草杆菌的MIC为0.8μg/m L,2,3-吡啶二羧酸对肺炎球菌的MIC为1.0μg/m L。

15 kinds of benzimidazole derivatives as antibacterial drug testing experiments, E. coli, and other 10 kinds of golden glucose cocci bacteria as bacteria tested by the statutory determination of the sample flat antibacterial activity. The results show that, in addition to succinic benzimidazole, other compounds have shown some antibacterial activity. Meanwhile through in vitro quantitative determination of the minimum inhibitory concentration of the sample（MIC）, the experimental results show that the compounds of the bacteria have good antibacterial activity, including 2-（2-（1H-benzo [d] imidazol-2- yl） pyridin-3-yl）-1H- benzo [d] imidazole, 2,3- pyridinedicarboxylic acid, 1,2-di（1H-benzo [d] imidazol-2-yl） ethane-1,2- diol, 2-phenyl-1H-benzo [d] imidazole has a broad spectrum of antibacterial activity against Bacillus subtilis 2,2＇-imidazole MIC was 0.8μg / m L, 2,3- dicarboxylic acid pyridine pneumococcal the MIC was 1.0μg / m L.