摘要
目的探讨血清白介素-15(interleukin-15,IL-15)水平与膝骨关节炎患者影像学改变程度的相关性。方法选择102名膝骨关节炎(osteoarthritis,OA)患者为OA组,54名健康体检者作为对照组。采用酶联免疫吸附法测定血清IL-15水平;采用Kellgren-Lawrence(KL)标准评价膝骨关节炎患者影像学改变的程度。结果 OA组KL2级、KL3级、KL4级患者的血清IL-15水平较对照组显著升高(均P<0.05)。OA组患者血清IL-15水平与KL分级呈显著正相关(r=0.433,P<0.01)。结论膝骨关节炎患者血清IL-15水平与影像学改变程度呈显著正相关。
Objective To understand any possible correlation of serum interleukin-15 （interleukin-15,IL-15） level to knee osteoarthritis （ OA） patients.Method 102 OA patients were chosen to be the experimental group and 54 healthy were chosen to be the control group. Serum IL-15 levels were determined by enzyme-linked immunosorbent assay. The radiographic disease severity of OA was assessed by Kellgren-Lawrence （ KL） grading system.The data obtained were then subjected to statistical analysis.Findings The serum IL-15 levels of the KL2 level, KL3 level, and KL4 level patients in the experimental group were significantly higher than those of the control group （P〈0.05）.The levels of serum IL-15 were found to be positively correlated with KL grading scores in the experimental group （r=0.433, P〈0.01）.Conclusion Serum IL-15 levels were associated with radiographic disease severity of OA patients.These results demonstrated that IL-15 might serve as a potential indicator of the severity and progression of knee OA.
出处
《健康研究》
CAS
2015年第2期164-165,170,共3页
Health Research
