13~2-N-(2-羟乙基)-15~3-N-(2-羟乙基)-17~3-甲氧羰基二氢卟吩e6-13~1-15~2-二酰胺的合成工艺及光学性质研究

Synthesis procedure and optical quality of 13~2-N-(2-hydroxyethyl)-15~3-N-(2-hydroxyethyl)-17^(-3)-methoxycarbonyl-chlorin e6-13^(-1)-15^(-2)-diamide and optical quality

本文以叶绿素-a为起始原料,经取代,加成等反应合成了一种新型叶绿素二氢卟吩衍生物132-N-(2-羟乙基)-153N-(2-羟乙基)-173-甲氧羰基二氢卟吩e6-131-152-二酰胺(Chlorin Amide e6,简称CAE),其化学结构均经UV-Vis,1H NMR,13C NMR及元素分析予以证实。通过对CAE合成工艺研究找到了最佳合成条件,并对光学性质和合成反应机理进行了研究。

On the basis of chlorophyll-a as starting material,a new chlorophyll chlorine derivative named 13 2-N-（2-hydroxyethyl）-153-N-（2-hydroxyethyl）-173-methoxycarbonylchlorine6-131-152-diamide（simple named CAE） was synthesized via a series of chemical reaction such as addition and substitution.The chemical structures of the unreported chlorin were characterized by UV-Vis,1H NMR,13 C NMR and elemental analysis.We find the optimum conditions of the synthesisits by researching synthesis procedure of CAE.At the same time,optical quali-ty and mechanism were also researched.