MTSS1在乳腺癌组织中的表达及其意义

Expression and clinical significance of metastasis suppressor 1 in breast cancer

目的:观察转移抑制因子1(metastasis suppressor 1,MTSS1)在乳腺癌、乳腺纤维瘤及正常乳腺组织中的表达,并探讨MTSS1与乳腺癌淋巴结转移间的关系。方法:采用免疫组织化学技术SP法检测70例乳腺癌、30例乳腺纤维瘤和70例乳腺正常组织中MTSS1的表达水平。结果:MTSS1在乳腺癌中的表达水平明显高于乳腺纤维瘤及正常乳腺组织(P<0.05)。结论:MTSS1表达水平可作为乳腺癌的辅助诊断指标,并可能是乳腺癌中晚期的有效预测指标。

ObjectiveTo observe the expression of metastasis suppressor 1 （ MTSS1 ） in breast cancer, fibroadenoma of breast and normal breast tissue and to explore the relationship between MTSS1 and lymph node metastasis.Methods：The MTSS1 expression in 70 cases of breast cancer, 30 cases of fibroadenoma of breast and 70 cases of normal breast tissue were detected by using immunohistochemical SP method .Results：The MTSS1 expression in breast cancer is significantly higher than that in fibroadenoma of breast and normal breast tissue .The difference was sig-nificant （P0.05）.Conclusion：MTSS1 expression can serve as an auxiliary diagnosis index in breast cancer, and may be an effective predictive in-dex for the breast cancer in middle -late stage.