新工艺制备的葛根黄酮的药代动力学研究

Pharmacokinetics of Puraria Flavanoids by New Technological Process

新工艺制备的葛根黄酮（ＰＦ）口服后５～１５ｍｉｎ血中即可检出，Ｔｍａｘ在０．６～１．６之间，其绝对生物利用度（小鼠）为１５．９１％。该药为一级动力学代谢，呈二室模型分布，体内药物吸收血药浓度随给药剂量的增加而增高。该药主要分布于肾、脾、心、肝等脏器，其在脑组织中虽分布较低，但其代谢较缓慢。其血浆蛋白结合率为４５．２２±１．２８％，该药主要从肠道排泄。

By the experiment of pharmacokinetics, it was showed that the puraria flavanoids (PF) by the new pharmacceutical process should be test from the blood after 5～15 min orally in both rat and mouse, with Tmax 0.6～1.6h. The absolute bioavailability of PF(0.2g/kg) was 15.91%. It did the metabolism as the first order kinetics with the distribution as a bicompartment model. There was the time-concentration relationship of PF in vivo. The organs distributed by PF were mainly kidney,spleen, heart, liver and lung. The concentration of PF in the brain was lower but diminished slowly. The combining percentage of the plasma protein of PF was 45.22±1.28%, and the evacuation from the body was mainly by intestinal tract.