良性前列腺增生症的遗传学进展

The progress in genetics of Benign prostatic hyperplasia

良性前列腺增生(benign prostatic hyperplasia,BPH)是前列腺上皮增生所致腺体增大而引起排尿受阻的病变,多发于中老年男性。虽然本质上不属于致命性疾病,但在病程的进展中严重影响中老年男性的生活质量,严重者会引起尿潴留,甚至肾脏功能紊乱,危害生命。然而,BPH的发病机制尚未明确,本文对BPH的遗传学研究进展加以综述,为相关研究提供证据。

BPH is the Prostate gland epithelial hyperplasia caused by an increase urination blocked lesions, mainly in middle-aged men.Although it is not belong to deadly disease, but seriously affect the quality of life in older men in the progression, serious one could caused urinary retention, kidney dysfunction and even endanger lives.However, pathogenesis of BPH is not yet clear.In this paper, we reviewed the progress of genetic research on BPH, provide evidence for related research.