microRNA参与脓毒症免疫调控机制研究进展

The Progress of the Immune Regulatory Mechanisms of microRNA involved in Sepsis

脓毒症是重症监护病房(ICU)患者死亡的重要原因之一,因其高患病率、高死亡率、高治疗费用的特点,以及缺乏有效的救治策略,使它成为人类健康的巨大威胁。免疫炎症反应失衡与脓毒症的发生发展密切相关,但其关键调控机制尚不清楚。微小RNA(micro RNA,mi RNA)在固有免疫反应和适应性免疫反应中起着重要作用。mi RNA通过调控炎症信号通路中关键分子的表达,从而影响脓毒症相关炎症因子的表达。因此,mi RNA可能成为在基因转录后水平诊断和治疗脓毒症的新靶点。

Sepsis is a major cause of death in the intensive care unit （ICU）, with high prevalence, high mortality, high cost of treatment, and the lack of effective treatment strategies. Sepsis has become a critical threat to human health. The imbalance of immune inflammation is considered to be closely associated with the development of sepsis, but the key mechanism underlying its regulation is unclear, miRNA has been shown to play an important role in regulation of the innate immune response and the adaptive immune response, miRNA controls the expression of inflammatory factors associated with sepsis by regulating the expression of the key molecules in inflammatory signaling pathway. Therefore, miRNA may become a novel posttranscriptional target in diagnosis and treatment of sepsis.