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麻风神经损伤机制研究进展 被引量:2

Research progress on mechanisms of nerve damage in leprosy
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摘要 麻风神经损伤是引起永久性损害而致畸、致残、丧失劳动力主要原因之一。了解麻风神经损伤的发病机制,对发现新的预防和治疗措施有很重要的作用,本文叙述了目前麻风神经损伤的机制和最新研究进展。 Nerve damage of leprosy is a major cause lead to malformation and disability.It is important to under-stand the pathogenesis of nerve damage for finding new prevention and treatment measures in leprosy.The mechanisms of nerve damage and recently research progress in leprosy were reviewed in this paper.
出处 《皮肤病与性病》 2015年第2期80-83,共4页 Dermatology and Venereology
关键词 麻风 神经损伤 leprosy Nerve damage
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  • 1Scollard DM, Adams LB, Gillis TP, et al.The continuing challenges of leprosy[ J] .Clin Microbiol Rev,2006,19(2) :338-381.
  • 2Tapinos N,Rambukkana A.Insights into regulation of human Schwann cell proliferation by Erkl/2 via a MEK-independent and p56Lck-de- pendent pathway from leprosy bacilli [ J ]. Proc Natl Acad Sci USA, 2005,102(26) :9188-9193.
  • 3Ohnishi M, Rambukkana A. ErbB2 receptor tyrosine kinase signaling mediates early demyelination induced by leprosy bacilli [ J] .Nat Med, 2006,12(8) :961-966.
  • 4Shimoji Y, Ng V, Matsumura K, et al. A 21-kDa surface protein of M y- cobacterium leprae binds peripheral nerve laminin- 2 and mediates Schwann cell invasion [ J ]. Proc Natl Acad Sci USA, 1999,96 ( 17 ) : 9857-9862.
  • 5Scollard DM. The biology of nerve injury in leprosy [ J ]. Lepr Rev,2008,79(3):242-253.
  • 6l'eles RM, Krutzik SR, Ochoa MT, et al.Interleukin-4 regulates the ex- pression of CD209 and subsequent uptake of Mycobacterium leprae by Sehwann cells in human leprosy [ J ]. Infect Immun, 2010,78 ( 11 ) : 4634-4643.
  • 7Rambukkana A,Zanazzi G,Tapinos N, et al.Contact-dependent demy- elination by Mycobacterium leprae in the absence of immune cells[ J]. Science, 2002,296 (5569) : 927- 931.
  • 8Rambukkana A. Mycobacterium leprae- induced demyelination: a model for early nerve degeneration [ J ]. Curr Opin Immunol, 2004,16 (4) :511-518.
  • 9Stoll G,Jander S,Myers RR. Degeneration and regeneration of the pe- ripheral nervous system: from Augustus Waller's observations to neu- roinflammation [ J] .J Peripher Nerv Syst,2002,7( 1 ) : 13-27.
  • 10Mattos KA, D'Avila H, Rodrigues LS, et al.Lipid droplet formation in leprosy: Toll- like receptor- regulated organelles involved in eicosanoid formation and Mycohaeterium leprae pathogenesis [ J ]. J Leukoc Biol,2010,87(3) :371-384.

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