不同程度房颤患者红细胞分布宽度、血浆高敏C反应蛋白水平、左心房直径变化

Changes of red blood cell distribution width,hs-CRP and left atria diameter in patients with varying degrees of atrial fibrillation

目的观察不同程度心房颤动(房颤)患者红细胞分布宽度(RWD)、血浆高敏C反应蛋白(hs-CRP)水平、左心房直径的变化,并探讨其与房颤程度的关系。方法房颤患者(房颤组)111例,其中阵发性房颤20例,持续性房颤40例,永久性房颤51例。选取年龄、性别、基础疾病与房颤组相匹配且无房颤病史的患者109例为对照组。采用全自动血细胞分析仪检测RWD,ELISA法检测血浆hs-CRP,超声心动图检查测量左心房直径。结果房颤组RDW、血浆hs-CRP水平、左心房直径分别为12.80%±0.91%、(2.50±0.62)ng/L、(37.92±6.38)mm;对照组分别为12.22%±0.26%、(1.07±0.58)ng/L、(33.65±4.70)mm;两组三项指标相比,P均<0.05。不同程度房颤患者随病情严重程度增加,RDW、血浆hs-CRP水平及左心房直径逐渐增高,阵发性、持续性、永久性房颤患者两两相比,P均<0.05。结论房颤患者RDW、血浆hs-CRP水平升高,左心房直径扩大,并与房颤的严重程度有关。

Objective To observe the changes of red blood cell distribution width （ RDW） , high-sensitivity C-reactive protein （hs-CRP） and left atrial diameter in patients with varying degrees of atrial fibrillation （AF）, and to investigate their relationship with disease severity.Methods Our study enrolled 111 patients with AF （ AF group） , including 20 ca-ses of paroxysmal AF, 40 cases of persistent AF and 51 cases of permanent AF.Another 109 subjects without AF history were selected as controls （ control group） who matched for sex, age and atherosclerotic risk factors.RWD was detected by automatic blood cell analyzer, ELISA was used to detect the plasma hs-CRP, and echocardiography was used to measure the left atrium diameter.Results The levels of RDW, hs-CRP and left atrial diameter in the AF and control groups were 12.80%±0.91%, （2.50 ±0.62） ng/L, （37.92 ±6.38）mm and 12.22%±0.26%, （1.07 ±0.58） ng/L, （33.65 ± 4.70） mm, respectively;and statistical difference was found （all P〈0.05）.Furthermore, RDW, hs-CRP and left atrial diameter were increased with the severity of AF types in subgroup analysis （all P〈0.05）.Conclusion The levels of RDW, hs-CRP and left atrial diameter of AF patients increase, which is related with the AF severity.