葡萄糖转运蛋白1在恶性胸腔积液的表达及意义

Expression of GLUT-1 in malignant pleural effusion and its clinical significance

目的评价葡萄糖转运蛋白l(GLUT-1)在恶性胸腔积液中的诊断价值。方法采用免疫细胞化学SP法检测肿瘤性和非肿瘤性胸腔积液中脱落细胞GLUT-1的表达以及ELISA法测定胸水中GLUT-1的水平。结果两组胸液脱落细胞GLUT-1的表达率恶性组为89.33%,良性组为3.17%,两组间具有统计学差异(P<0.01);两组胸液上清中GLUT-1的表达水平恶性组为(1.18±0.35)pg/ml,良性组为(0.85±0.24)pg/ml,两组间具有统计学差异(P<0.05)。结论 GLUT-1对恶性胸腔积液的诊断具有较高的敏感度,可以作为鉴别恶性胸腔积液的可靠标记之一。

Objective To investigate the diagnostic value of glucose transporter-1 （ GLUT-1 ） in malignant pleural effusion. Methods The levels of GLUT-1 in neoplastic pleural effusion and non-neoplastic pleural effusion exfoliated cells were determined by immunohistochemistry SP method, and the levels of GLUT-1 in pleural effusion serum were detected by enzyme-linked immunosorbent assay. Results The expression of GLUT-1 of pleural effusion exfoliated cells in the malignant group was 89. 33% and 3. 17% in the benign group （P 〈0. 01）. the levels of GLUT-1 of pleural effusion serum t were （1. 18 ± 0. 35） pg/ml in the malignant group and （0. 85 ± 0. 24） pg/ml in the benign group （P〈0. 05）. Conclusion GLUT-1 has a higher sensitivity in diagnosis of malignant pleural effusions, which can be used as a reliable marker in identification of malignant pleural.