瑞舒伐他汀与氟伐他汀对不稳定型心绞痛患者的调脂作用研究

The Study of Lipid Regulating Effects of Rosuvastatin and Fluvastatin for Patients with Unstable Angina

目的:探讨瑞舒伐他汀与氟伐他汀对不稳定型心绞痛(unstable angina,UA)的调脂作用的临床疗效。方法:将98例UA患者随机分为观察组和对照组,每组各49例患者。在常规治疗包括硝酸酯类、抗血小板药物、钙离子拮抗剂和抗凝血药物基础上,对照组加服氟伐他汀20 mg,口服1次/晚;观察组加服瑞舒伐他汀10 mg,口服1次/晚,两组观察时间均为8周,观察两组的临床疗效和治疗前后血脂及C-反应蛋白(C-response protein,CRP)浓度的变化情况。结果:两组患者的临床症状均改善,观察组与对照组比较,有效率分别为93.88%和79.59%,两组比较差异有统计学意义(P<0.05);血总胆固醇、甘油三酯、低密度脂蛋白及CRP浓度明显降低(P<0.05);血高密度脂蛋白明显升高(P<0.05)。结论:瑞舒伐他汀和氟伐他汀均可以改善不稳定型心绞痛患者的临床症状,调脂作用效果明显,而瑞舒伐他汀的效果更好于氟伐他汀。

Objective： To investigate the rosuvastatin and fluvastatin clinical efficacy of statin lipid-lowering effects of unstable angina.Method ： 98 cases were randomly divided into observation group and control group, 49 cases in each group.In the conventional treatment including nitrates, anti-platelet drugs, calcium antagonists and anti-clotting drugs on the basis of that, the control group was took fluvastatin 20 rag, orally once every night; observation group was took rosuvastatin 10 rag, orally once every night, ,the observation times of two groups were 8 weeks.The clinical efficacy and changes of before and after treatment of lipid and C-reactive protein （ C-response protein, CRP ） concentrations in both groups were Observed.Result： The clinical improvement in symptoms of both groups, compared with the control group, the response rate was respectively 93.88% and 79.59% （ P〈0.05 ） ; total cholesterol, triglycerides, LDL and CRP levels of observation group were significantly lower, the differences were statistically significant （P〈0.05） ; serum high-density lipoprotein of observation group significantly increased, the difference was statistically significant （ P〈0.05 ） . Conclusion： Aosuvastatin and fluvastatin can＇ improve clinical symptoms in patients with unstable angina, lipid effects obvious, and rosuvastatin are better than fluvastatin.