SCF/C-Kit在子宫腺肌瘤和子宫内膜异位症患者在位和异位内膜中的表达和意义

The expression and significance of SCF/C-Kit in ectopic and eutopic endometrium of the patient with endometrioma and endometriosis

目的探讨子宫腺肌瘤和子宫内膜异位症(内异症)患者在位、异位内膜中干细胞因子(SCF)及其C-Kit的表达,从而了解SCF及其受体C-Kit分别在子宫腺肌瘤和内异症发病中的作用。方法采用免疫组化法,检测各组在位内膜及异位内膜组织SCF、C-Kit的表达。结果本研究各组均表达SCF和C-Kit,SCF的表达在研究组中较对照组明显增强,差异均有统计学意义(子宫腺肌瘤组P<0.01;内异症组P<0.05),在腺肌病患者中在位内膜分泌期的表达明显增高,分泌期>增生期(P<0.01),在位内膜>异位内膜(P<0.05);在巧克力囊肿患者中,在位内膜分泌期的表达较在位内膜增生期和异位内膜及对照组各期均增高,差异有统计学意义(P<0.05),而较子宫腺肌瘤低,但差异无统计学意义(P>0.05);C-Kit在腺肌病患者中的表达较巧克力囊肿组和对照组增高,差异有统计学意义(P<0.05),在位内膜分泌期的表达较在位内膜增生期和异位内膜及对照组各期均增高,差异有统计学意义(P<0.05)。结论 SCF、C-Kit可能是子宫内膜腺肌瘤和子宫内膜异位症的重要发病原因之一。

Objective To study the expression of stem cell factor （SCF） and its receptor C-Kit in ectopic and eutopic endometrium in patients with endometdoma and endometriosis, to investigate the effect of SCF and its receptor C-Kit in pathogenesis in the endometrioma and endomctriosis. Methods Immunohistochemical method was used to examine the expression of SCF and C-Kit in the＇eutopic and ectopic endometrium. Results All groups were expressing SCF and C-Kit, but the expression of SCF was enhancer in observation groups than contrast group. These differences were all statistical significance （the group of endometrioma was P〈0.01, and the group of endometriosis was P〈0.05）. The expression of secretory phase in eutopic ~ndometrium of the endometrioma was enhancer, which was greater than proliferative phase （P〈0.01）, the eutopic endometrium was also greater than ectopic endometrium （P〈0.05）. In the chocolate cysts, the expression of secretory phase of endometrium was enhancer than proliferative stage of endometrium and ectopic endometrium and every phases of contrast group, which were statistical significance （P〈0.05）, but it was under than endometrioma, and the differences were not statistical significance （P〉0.05）. The expression of C-Kit in the adenomyomatosis was higher than chocolate cyst 4 group and contrast group （P〈0.05）, which was statistical significance. The expression of endometrium in the secretory phase was higher than its proliferative phase and each phase of ectopic endometrium, and contrast group too, which was statistical significance （P〈0.05）. Conclusion The SCF/C-Kit may play an important role in pathogeny of the adenomyoma and endometriosis.