摘要
乙型肝炎病毒(HBV)感染是一个影响全人类健康的公共卫生问题,全球大约有3.5亿慢性HBV携带者。HBV主要传播途径为母婴垂直传播,其中宫内感染被认为是母婴垂直传播的重要途径之一,是造成免疫预防失败的主要原因。已有研究证实胎盘组织、外周血单个核细胞(PBMCs)、生殖细胞在HBV宫内感染中扮有重要角色。本文将对HBV发生宫内感染的高危因素及其产生机制进行综述。
Hepatitis B virus （HBV） infection is a major public health problem. An estimated 350 million people are chronic carriers of HBV. Mother-to-infant transmission of HBV is the most common route of infection. Intrauterine transmission of HBV is one of the main reasons for the immunoprophylaxis failure. Studies have showed that placental tissues, peripheral blood mononuclear cells （PBMCs） and germ cells played important roles on HBV intrauterine infection. The research progress of mechanism of HBV intrauterine transmission and its high factors were reviewed in this paper.
出处
《中华临床医师杂志（电子版）》
CAS
2015年第8期133-136,共4页
Chinese Journal of Clinicians(Electronic Edition)
基金
军队十二五面上项目(CWS11J161)
关键词
肝炎病毒
乙型
宫内感染
高危因素
Hepatitis B virus
Intrauterine transmission
Risk factors
