二甲双胍对非肥胖型多囊卵巢综合征性激素水平的干预作用观察

To observe the therapy effects of metformin on non-obese women with polycystic ovary syndrom

目的针对二甲双胍联合达英35对非肥胖型多囊卵巢综合征的治疗效果进行评价。方法选取诊断为PCOS的非肥胖患者500例,随机分为观察组(268例)和对照组(232例),观察组采用二甲双胍联合达英35治疗3个月;对照组采用达英35治疗3个月。将2组治疗前后的临床表现、性激素水平进行对照分析。结果和结论 1、达英-35联合二甲双胍及单纯应用达英-35治疗非肥胖型PCOS,均可改善患者的临床症状,降低患者T,LH水平。2、达英-35联合二甲双胍较单纯应用达英-35治疗非肥胖型PCOS,降低高雄激素血症效果更明显。

Objective To observe the therapy effects of Metformin and Diane-35 on non-obese women with polycystic ovary syndrome. Methods 500 non-obese women with polycystic ovary syndrome as samples,which were divided to observation group （268 case） and matched group （232 case）. In the observation group,all cases were treated with Mefformin and Diane-35 for 3 months,and in the matched group,all the cases were only treated with Diane-35 for 3 months.To compare the two group patients＇clinical presentations and sex hormone.Results and Conclusion 1. The two treatments all improved patients＇ clinical presentations. 2.The method of Metformin and Diane-35 were superior to the method of only Diane-35 on lowering hyperandrogenism.