子代孤独症与母亲基础性激素水平的关联性

Association between autism in offspring and the basic levels of sex steroids in mothers

目的 探讨孤独症患儿母亲与正常儿童母亲基础性激素水平的差异,以及母亲基础性激素水平与孤独症症状严重程度的相关性.方法 利用化学发光法对62例孤独症患儿母亲及29例正常儿童母亲血清睾酮（T）、孕酮（P）、雌二醇（E2）、硫酸脱氢表雄酮（DHEA-S）、雄烯二酮（A）水平进行检测,并对弧独症组患儿分别进行孤独症诊断会谈问卷修订版（ADI-R）、孤独症诊断观察量表（ADOS）、中国韦氏儿童智力量表（C-WISC）/中国韦氏幼儿智力量表（C-WYCSI）、婴幼儿发育检查量表评估.结果 孤独症组母亲血清E2水平（35.00 pg/ml,IQR 27.00 - 44.50）较正常对照组（48.00 pg/ml,IQR 30.00- 59.50）低,差异有统计学意义（P=0.03）,而孤独症组与对照组母亲血清T（0.29 ng/ml,IQR 0.24-0.31;0.32 ng/ml,IQR 0.23-0.40）、P（0.20 ng/ml,IQR 0.19-0.30;0.20 ng/ml,IQR 0.10-0.30）、DHEA-S （5.57 μmol/L,IQR 4.19-7.12;4.95 μmol/L,IQR 3.70-7.11）、A（5.85 nmol/L,IQR 4.33 - 8.27;6.23 nmoL/L,IQR 4.48 - 7.16）、E2 ＊/T（1.23,IQR 0.93-1.94;1.27,IQR 0.89-2.31）比较均差异无统计学意义;且孤独症患儿母亲血清E2低水平与患儿性别、智商（或发育商）及ADI-R、ADOS评分无相关性.结论 孤独症患儿母亲基础雌二醇水平降低,提示母亲低雌激素水平可能与孤独症发生有关.

Objective To investigate the difference of basic levels of sex steroids between mothers with autistic and normal children,and the relationship between severity of symptom in autistic children and the levels of sex steroids in their mothers.Methods The serum levels of testosterone （T）,progesterone （P）,estradiol （E2）,dehydroepiandrosterone sulfate（DHEA-S） and androstenedione （A） in 62 mothers with autistic children and 29 with normal children were measured with chemiluminescent immunoassay.The autistic children were tested with Chinese version of the Autism Diagnostic Interview-Revised （ADI-R）,Autism Diagnostic Observation Schedule （ADOS）,Wechsler Intelligence Scale of Children（C-WISC） or Young Children（C-WYCSI） and Gesell Developmental Schedule to assess their symptom.Results The serum levels of E2 in mothers with autistic children （35.00 pg/ml,IQR 27.00-44.50） were significantly lower（P=0.030） than those in mothers with normal children （48.00 pg/ml,IQR 30.00-59.50）,which was not associated with sex,intelligence （or developmental quotient） and the scores of ADI-R and ADOS of their offsprings.However,there were no significantly differences in the serum levels of T （0.29 ng/ml,IQR 0.24-0.31;0.32 ng/ml,IQR 0.23-0.40）,P （0.20 ng/ml,IQR 0.19-0.30;0.20 ng/ml,IQR 0.10-0.30）,DHEA-S （5.57 μmol/L,IQR 4.19-7.12;4.95 μmol/L,IQR 3.70-7.11）,A （5.85 nmol/L,IQR 4.33-8.27;6.23 nmol/L,IQR 4.48-7.16）,E2＊/T （1.23,IQR 0.93-1.94;1.27,IQR 0.89-2.31） between mothers in the two groups.Conclusion The serum levels of E2 in mothers with autistic children were decreased,suggesting that the lower level of maternal E2 may be associated with autism.