替吉奥联合奥沙利铂与替吉奥单药治疗老年晚期胃癌的临床比较研究

Clinical Comparison Research of Chemotherapy Regimen of S-1 plus Oxaliplatin and S-1 for Elderly Patients with Advanced Gastric Cancer

目的比较替吉奥联合奥沙利铂与替吉奥单药治疗老年晚期胃癌的临床疗效及毒副反应。方法70例晚期胃癌老年患者随机分为2组,联合组37例予以替吉奥联合奥沙利铂化疗,单药组33例仅接受替吉奥治疗。结果与单药组比较,联合组治疗有效率和疾病控制率均显著提高(P<0.05),但不能延长患者生存时间和提高患者生活质量(P>0.05);同时,联合组毒副反应也相应增加,骨髓抑制、外周神经毒性发生率均明显升高(P<0.05)。结论与单用替吉奥比较,替吉奥联合奥沙利铂治疗老年晚期胃癌可提高临床疗效,但安全性、耐受性及生存获益仍需扩大样本量进一步研究。

Objective To compare the efficacy and toxicities of S-1 plus oxaliplatin and S-1 for elderly patients with advanced gastric cancer. Methods Seventy elderly patients with advanced gastric cancer were divided into two groups,S-1 plus oxaliplatin chemotherapy was administered to the S-1 plus oxaliplatin group（ n=37 ）,and the S-1 group（n=33）received S-1 only. Results Compared with the S-1 group,the effective rate and the disease control rate of the S-1 plus oxaliplatin group were significantly higher（P〈0. 05）;the survival time was no longer and the quality of life was no better in the S-1 plus oxaliplatin group（P〉0. 05）. The incidences of marrow depression and peripheral neurotoxicity in the S-1 plus oxaliplatin group were significantly higher than those in the S-1 group（ P〈0. 05）. Conclusion S-1 plus oxaliplatin can improve the clinical efficacy,but whether it can increase the safety, tolerance and quality of life need the further study.