43例小细胞肺癌临床病理特征分析

Analysis of Clinicopathological Features of 43 Patients with Small Cell Lung Carcinoma

目的探讨小细胞肺癌(SCLC)临床病理特征及免疫组化特点,提高SCLC的确诊率。方法回顾性分析43例SCLC患者的临床病理资料。结果常规HE染色可见细胞较小,挤压变形,核浆比增大。免疫组化结果显示:CD56阳性率100.0%(43/43);NSE、Cg A、Syn阳性率分别为46.5%(20/43)、23.3%(10/43)及39.5%(17/43);AE1/AE3阳性率27.9%(12/43);TTF-1阳性率51.2%(22/43);Ki-67全部病例有强弱不等的阳性表达,指数>60%者33例,占76.7%。结论 SCLC组织切片中细胞易挤压变形,CD56阳性和Ki-67指数>60%有助于其确诊。

Objective To investigate the clinicopathological and immunohistochemical features of small cell lung cancer （SCLC） , and to improve the diagnosis rate of SCLC. Methods The clinicopathological data of 43 patients with SCLC were analyzed retrospectively. Results HE stain result showed： the SCLC cells were small and extrusion deformation, the nucleocytoplasmic ratio was increased, immunohistochemical stain result showed： the positive rate of CD56 was 100.0% （43/43） ,NSE 46.5% （20/43）, CgA 23.3% （ 10/43 ）, Syn 39.5% （ 17/43 ）, AE1/AE3 27.9% （12/43）,TTF-151.2% （22/43）,Ki-67 （theindex〉60%）76.7% （33/43）.Conclusion SCLC biopsy cells are extrusion deformation, CD56 positive and Ki-67 index 〉 60% help to the diagnosisof SCLC.