肺癌患者化疗前后凝血、纤溶功能及血小板参数的变化及其临床意义

The Changes of Coagulation,Fibrinolysis Function and Platelet Parameters of Patients with Lung Cancer and Their Clinical Significance

目的研究肺癌患者化疗前后凝血、纤溶功能及血小板参数的变化及其临床意义。方法 56例肺癌患者肺癌患者化疗前后凝血、纤溶功能及血小板参数的变化被检测,并以56例健康体检者作为对照。结果肺癌患者血浆纤维蛋白原、血小板计数和血小板体积分布宽度分别为(4.31±0.75)g·L-1、(287.41±97.56)×109·L-1和16.01±2.86 fl,健康体检者分别为(3.19±0.46)g·L-1、(205.62±51.97)×109·L-1和(15.12±1.57)fl,比较差异均有统计学意义(P均<0.05)。化疗后肺癌患者凝血酶原时间由化疗前的(11.35±0.86)s减少为(10.21±0.65)s,血小板计数由(287.41±97.56)×109·L-1减少为(207.05±81.36)×109·L-1,血红蛋白由(125.79±31.08)g·L-1减少为(108.20±25.74)g·L-1,比较差异均有统计学意义(P均<0.05)。结论化疗可能导致肺癌患者的凝血、纤溶功能异常。

Objective To research the changes of coagulation,fibrinolysis function and platelet parameters of patients with lung cancer and their clinical significance. Methods The changes of coagulation,fibrinolysis function and platelet parameters of the 56 patients with lung cancer were detected before and after treatment,and those of the healthy volunteers were detected too. Results The fibrinogen,platelets and platelet distribution width of the patients with lung cancer were（4. 31 ± 0. 75）g·L^-1 ,（287. 41 ± 97. 56）× 10^9 ·L^-1 and（16. 01 ± 2. 86）fl;those of the healthy volunteers were（3.19±0.46）g·L^-1,（205.62 ±51.97）×10^9·L^-1 and（15.12 ±1.57）fl（P〈0. 05）. After the chemotherapy,the prothrombin time of patients with lung cancer decreased from（11. 35 ± 0. 86）s to（10.21 ± 0. 65）s,the platelets decreased from（287. 41 ± 97. 56）× 10^9 ·L^-1 to（207. 05 ± 81. 36）× 10^9·L^-1,the hemoglobin decreased from（125.79 ±31.08）g·L^-1 to（108.20 ±25.74）g·L^-1（P〈0.05）. Conclusion The chemotherapy can induce the changes of coagulation and fibrinolysis function of the patients with lung cancer.