肝癌患者TACE术后血清VEGF、HIF-1α、CRP水平与肝癌复发的相关性分析

Correlation Analysis of Serum VEGF,HIF-1 Alpha,CRP Levels and HCC Recurrence in Patients with Hepatocellular Carcinoma After TACE Operation

目的观察肝癌患者在TACE术后血清VEGF、HIF-1α、CRP水平与肝癌复发的相关性。方法选择2010年1月至2012年1月在成都医学院第一附属医院肿瘤科住院采用TACE方式进行治疗的肝细胞癌患者60例为肝癌组,以同期住院的60例肝脏良性病变患者为对照,在肝癌组患者TACE术后1周时检测其血清VEGF、HIF-1α、CRP水平,与对照组的血清VEGF、HIF-1α、CRP水平进行比较,将肝癌组患者按复发情况分类后,观察VEGF、HIF-1α、CRP与复发的关系,统计VEGF、HIF-1α、CRP预测复发的敏感性、特异性。结果肝癌组患者的血清VEGF、HIF-1α、CRP水平明显高于对照组,差异具有统计学意义;VEGF、HIF-1α、CRP水平升高与肝癌复发存在相关性,具有统计学意义;VEGF与肝癌复发的敏感性73.4%、特异性81.25%,HIF-1α的敏感性79.6%、特异性83.3%,CRP的敏感性69.4%、特异性71.4%。结论肝癌患者TACE术后血清VEGF、HIF-1α、CRP水平可以预测肝癌的发生情况,VEGF、HIF-1α的敏感性与特异性要好于CRP。

Objective To investigate the correlations of serum levels of VEGF, HIF-1 alpha, CRP level and HCC recurrence in patients with hepatocellular carcinoma after TACE operation. Methods Sixty cases of hepatocellular carcinoma（ HCC ）patients with TACE manner treatment （hepatocellular carcinoma group ）and 60 patients with benign liver lesions （control group）were selected and involved in this study. The serum levels of VEGF, HIF-1 alpha and CRP in hepatocellular carcinoma group after one week of TACE operation and in control group were detected. The relationship between VEGF, HIF-1 alpha, CRP and recurrence in patients with hepatocellnlar carcinoma was analyzed. Results The serum VEGF, HIF-1 alpha and CRP levels in patients with hepatocellular carcinoma were significantly higher than those in the control group （ P 〈 0.05 ）. The increase of VEGF, HIF- 1 alpha, CRP levels were correlated with HCC recurrence exists（P 〈 0.05 ）. The sensitivity and specificity between VEGF and recurrence of HCC were 81.25% and 73.4%. The sensitivity and specificity between HIF- 1 alpha and recurrence of HCC were 79.6% and 83.3%. The sensitivity and specificity between CRP and recurrence of HCC were 69. 4% and 71. 4%. Conclusion The serum VEGF, HIF-1 alpha and CRP levels in patients with hepatocellular carcinoma after operation could predict the occurrence of hepatocellular carcinoma.