对氧磷酶-1与多囊卵巢综合征关系的研究进展

Research progress on relationship between paraoxonase 1 and polycystic ovary syndrome

多囊卵巢综合征(PCOS)是育龄期妇女常见的内分泌代谢紊乱性疾病之一。该病患者常伴肥胖、胰岛素抵抗、糖代谢和脂代谢异常、氧化应激增加、亚临床慢性炎症等,可明显增加代谢综合征、2型糖尿病的发生率以及心血管疾病的发生风险。对氧磷酶(PON)1是高密度脂蛋白(HDL)的重要抗氧化酶之一,具有抗氧化、抗炎症和抗动脉粥样硬化的作用。笔者拟就PON1基因变异、PON1蛋白结构和生理功能以及PON1与PCOS关系的研究进展进行综述如下。

Polycystic ovarian syndrome （PCOS） is one of the most common endocrine metabolic disorders. It is often associated with obesity, insulin resistance, dyslipidemia, increased oxidative stress, systemic low-grade chronic inflammation, elevated prevalenees of metabolic syndrome and type 2 diabetes, and potentially increased the risks of atherosclerosis and cardiovascular disease. Paraoxonase （PON） 1 is one of high-density lipoprotein （HDL）-associated antioxidant enzymes. It possesses antioxidant, anti- inflammatory and anti-atherogenic properties. In this article, we will summarize the research progress on the genetic variations, enzyme activities and physiological functions of PON1 and their relationship to PCOS.