紫杉醇及其制剂的研究进展

Research Progress of Paclitaxel and Its Preparation

紫杉醇属于二萜类化合物,是第一个来自天然植物用来治疗癌症的化学药物,现已被广泛用于治疗癌症中的卵巢癌、乳腺癌、肺癌等。由于其抗癌作用机理独特有效,因此作为新型抗癌药越来越受到各国的重视。详细介绍了紫杉醇的理化性质、作用机制和来源。提出针对紫杉醇自身水溶性差、资源匮乏的问题,应加快研发具有与紫杉醇机理相同的紫杉醇衍生物或其他活性成分的药物,开发发酵、全合成等制备紫杉醇的新方法。

Paclitaxel which belongs to diterpenoid compound is the fast chemical drug that comes from natural plants and used to treat cancers. Now it has been widely used in the treatment of ovarian cancer, breast cancer and lung cancer etc.. Due to the unique and effective anticancer mechanism of paclitaxel, as a novel antieancer drug, paelltaxel has caused more and more attention from every country. The physical and chemical properties, mechanism of action and the source of paelitaxel were introduced in detail. Aming at the problems that paelitaxel is poor water solubility and lacking of resources, the solutions are accelerating the speed of developing paelitaxel derivatives that has the same mechanism as paclitaxel or other active ingredient drugs, developing new methods for preparation of paclitaxel such as fermentation, total synthesis etc..