腺嘌呤导致慢性肾衰模型大鼠的钙磷代谢变化

The Changes of Calcium-Phosphorus Metabolism in Chronic Renal Failure Rats due to Adenine

目的观察慢性肾衰模型大鼠的钙磷代谢变化,为慢性肾衰并发症的防治提供理论依据。方法 SD大鼠20只随机分为对照组(Ctr,n=10)、慢性肾衰组(CRF,n=10)。每天分别以生理盐水(10 ml/Kg)、腺嘌呤(300 mg/Kg)灌胃6周。化学比色法检测血磷和血钙。结果 CRF组血磷和血钙水平与Ctr组相比,差异显著(P<0.05)。结论慢性肾衰时,血磷水平升高和血钙水平降低。

Objective To observe the changes of calcium- phosphorus metabolism in chronic renal failure rats and provide a theoretical basis for preventing the complications of chronic renal failure. Methods Twenty SD males rats had been randomly divided into the control group （Ctr, n=10）, chronic renal failure group （CRF, n=10）. The rats in Ctr and CRF group were respectively dealed with normal saline （10 ml/Kg） and adenine （300 mg/Kg） intragastrically daily . Six weeks later, the concentration of Calcium, Phosphorous in Serum were biochemical analysised. Results The concentration of Calcium, Phosphorous in Serum was signiifcant differences between two groups （P〈0.05）. Conclusion The levels of serum phosphrous in CRF were signiifcantly higher than those in the Ctr, however, the levels of blood calcium was lower.