利培酮与氯氮平治疗精神分裂症临床对比分析

Clinical Comparison Analysis on Risperidone and Clozapine in The Treatment of Schizophrenia

目的：分析利培酮和氯氮平治疗精神分裂症的临床效果。方法选取我院2013-2014年的91例患者来进行研究分析，分组为利培酮和氯氮平组，前组有42例患者，后组有49例患者，分析两组的精神病量表（BPRS）、阳性症状量表（SAPS）、副反应量表（TESS）。结果利培酮组患者的显效时间为一至两周，平均（10.56±4.23）天，氯氮平为一周左右，平均（7.23±3.57）天，差异无统计学意义，P〉0.05。利培酮组有36例显效，氯氮平组有38例显效，两组的治疗效果差异无统计学意义。量表结果显示，两种药物均对精神分裂症阳性症状改善明显，氯氮平组的BPRS和SAPS评分比利培酮组高，差异有统计学意义，P〈0.05，说明利培酮对激活性及怪异行为症状群疗效略差，而其它症状群疗效相似。结论利培酮和氯氮平的临床治疗效果均比较优秀，利培酮的优势更大一些。

Objective To study the clinical analysis of the effect of risperidone and clozapine in the treatment of schizophrenia. Methods 91 patients in our hospital from 2013 to 2014 were selected into risperidone group（42 cases）and clozapine group（49 cases）. Brief Psychiatric Rating Scale（BPRS）, scale for assessment of positive symptoms（SAPS）,treatment emergent symptom scale（TESS）of two groups were analyzed. Results The action time of risperidone group was one to two weeks,with an average of（10.56±4.23）d,and the clozapine group was about one week ,with an average of （7.23±3.57）d. The difference was not significant,P〉0.05. There were 36 excel ent cases in risperidone group,38 excel ent cases in clozapine group, and the difference of clinical effects were not significant. The clinical effects of two drugs to the positive symptoms of schizophrenia were obvious ,the BPRS and SAPS scores in clozapine group was higher than risperidone group significantly,P〈0.05. The clinical effect of risperidone to the activation and bizarre behavior symptoms was worse,and was similar for other symptoms. Conclusion The clinical effect of risperidone and clozapine in the treatment of schizophrenia are excel ent,and the advantages of risperidone are greater.