连续性血液滤过在治疗儿童多脏器功能障碍综合征中的作用和意义

The Significance of Continuous Veno-Venous Hemofiltration for Treating Pediatric Multiorgan Dysfunction Syndrome

目的探讨连续性静脉血液滤过(CVVH)治疗儿童多脏器功能障碍综合征(MODS)的作用及意义。方法 45例MODS患儿采用CVVH治疗,检测CVVH治疗前及治疗中各时相点血气、生化、细胞因子浓度指标、血管活性药物用量、血压、尿量等变化。结果 45例MODS患儿经过CVVH治疗及其他综合治疗,11例MODS患儿死亡,余34例均治愈出院,治愈率75.6%。结论 CVVH联合其他综合治疗可明显改善MODS患儿的氧合,纠正酸中毒、清除炎症介质、代谢产物,稳定血压,改善组织器官灌注,促进脏器功能恢复。

ObjectiveTo signification of continuous veno-venous hemofiltration （CVVH） for treatment pediatric multiorgan dysfunction syndrome （MODS）.MethodsSelected 45 children with MODS were treated with CVVH. Examined at a set of time points from the beginning＆amp;nbsp;to the end of CVVH included the blood gas, biochemical items, cytokine concentration, dosage of vascular active drug, blood pressure （BP）, urine output.Results45 cases of children with MODS after CVVH therapy and other comprehensive treatment, 11 cases of children with MODS died and 34 cases were cured, the cure rate of 75.6%.Conclusion The CVVH and other comprehensive treatment is effective in treatment of pediatric MODS by improving the oxygenation, correcting metabolic acidosis, eliminating the inlfammatory mediators and metabolites, stabilizing BP, increasing the tissue perfusion and promoting the viscera function recovery.