阿托伐他汀钙对冠心病心功能不全患者肾功能的保护作用

To Explore the Protective Effects of Atorvastatin Calcium on Coronary Heart Disease Patients With Cardiac Insufficiency of Kidney Function

目的分析探讨阿托伐他汀钙药物是否降低冠心病心功能不全患者的肾功能损害,对其产生保护作用。方法以45例冠心病心功能不全并伴有肾功能异常的患者作为研究对象,将其随机分为治疗组和对照组,对照组22例患者采用常规药物进行治疗,治疗组23例患者在常规治疗基础上联合阿托伐他汀钙共同进行治疗,对45例患者进行治疗后随访,对比分析两组患者治疗前后的肾功能指标情况。结果两组各有21例患者参加治疗后第12个月肾功能情况的对比分析。治疗组21例患者的肾功能指标(肾小球滤过率和胱抑素)优于对照组的21例患者,P<0.05,差异具有统计学意义,而两组患者的2微球蛋白指标,P>0.05,差异不具有统计学意义。结论应用阿托伐他汀钙药物对冠心病心功能不全并伴有肾功能异常的患者进行辅助治疗,可明显降低其肾功能的损害程度,产生保护作用。

Objective To explore whether atorvastatin calcium drugs decreased heart function of coronary heart disease in the patients with renal insufifciency have a protective effect on the damage.Methods In 45＆amp;nbsp;patients with coronary heart disease cardiac dysfunction and associated with abnormal renal function as the object of study, which were randomly separated into treatment group and control group, 22 cases in the control group were treated with routine drug treatment, treatment group based on conventional therapy plus atorvastatin calcium common treatment, 45 patients were followed up after the treatment, the contrast analysis of renal function indexes of two groups of patients before and after treatment. ResultsTwo groups compared with patients in twelfth months after treatment renal function condition. The treatment group of 21patients with renal function index 21 cases were signiifcantly better than the control group of patients, but no significant difference between all patients2 microglobulin index （P＆gt;0.05）.Conclusion Atorvastatin calcium drugs on coronary heart disease cardiac dysfunction and associated with abnormal renal function in patients with adjuvant therapy, can significantly reduce damage of kidney function.