摘要
嗜吞噬细胞无形体是一种革兰阴性菌,专性细胞内寄生,可经蜱传播。主要侵染宿主的髓系细胞和非髓系细胞,引起动物蜱传热病和人粒细胞无形体病。论文总结了近年来与嗜吞噬细胞无形体入侵宿主细胞相关的蛋白质,如主要表面蛋白MSP2、外膜蛋白OmpA、嗜吞噬细胞无形体表面蛋白AipA等的研究成果,以及该病原菌进入宿主细胞后引起的宿主细胞的变化,如激活一系列蛋白激酶、抑制氧化反应和炎症反应、干扰自噬作用等影响及其可能的机制。关于嗜吞噬细胞无形体,还有很多领域的问题亟待研究解决,国内外许多学者致力于研究该病原菌与宿主细胞的互作,以期找出嗜吞噬细胞无形体如何影响宿主细胞的信号传导和相关基因的表达,从而逃避宿主免疫系统并在其中正常生存的机制。
A. phagocytophilum is a Gram-negative and obligate intracellular pathogen transmitted by ixodid ticks. This bacterium predominantly invades myeloid and nonmyeloid cells and causes tick-borne fever in animals and granulocytic anaplasmosis in humans. Here, we provided an overview on research of the related proteins involved in A. phagocytophilum invasion into host cells, such as major surface protein MSP2, outer membrane protein OmpA, A. phagocytophilum surface protein AipA. What＇s more, we also focused on the effects of A. phagocyto- philurn on host cells after its invasion and the underlying mechanisms. The influences such as activation of some protein kinases, downregulation of oxidative and inflammatory response, subversion of host apoptosis and autoph- agy were summarized in this paper. However, many scientific gaps about A. phagocytophilum are needed to fill currently. Fortunately, a large amount of researchers are focusing on how A. phagocytophilum influences cellular signal transduction and expressions of some related genes in neutrophils through investigating the interaction of the pathogen and the host cell to explore the underlying mechanisms that the bacterium can escape host immune system and survive in it.
出处
《动物医学进展》
北大核心
2015年第5期95-98,共4页
Progress In Veterinary Medicine
基金
国家现代肉羊产业技术体系建设专项(nycytx-39)
