通心络对2型糖尿病合并冠心病患者GSH-PX SOD和MDA的影响

Effect of Tongxinluo on GSH-Px SOD and MDA in Diabetes Patients with CHD

目的:探讨通心络对2型糖尿病合并冠心病患者谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)、丙二醛(MDA)的影响。方法:60例2型糖尿病合并冠心病患者随机分为对照组和通心络组,每组30例。观察两组治疗前后患者血清氧化应激指标:GSH-PX、SOD及MDA。结果:治疗后通心络组患者血清GSH-Px、SOD活性[(213.5±53.2)mg/L,(55.37±10.36)μ/m L],较治疗前[(153.4±45.9)mg/L,(41.35±7.63)u/m L]显著升高,治疗后MDA水平[(8.2±0.83)nmo L/m L],较治疗前[(13.9±0.76)nmo L/m L]显著降低,差异有统计学意义(P<0.01),且治疗后通心络组与对照组GSH-Px、SOD[(186±38.6)mg/L,(48.18±7.87)u/m L]比较,差异有统计学意义(P<0.05),MDA[(9.54±1.07)nmo L/m L]与对照组比较差异显著(P<0.01)。结论:通心络能提高2型糖尿病合并冠心病患者血清GSH-Px及SOD水平,降低MDA活性,可改善氧化应激状况。

Objective：To research the effects of Tongxinluo on glutathione peroxidase （ GSH-Px） , su-peroxide dismutase （ SOD） and Malondialdehyde （ MDA） in diabetes patients with coronary heart disease . Mtehod：Sixty diabetes patients with coronary heart disease were randomized into groups control and Tongx -inluo group,30 cases in each group.Serum oxidative stress marker such as GSH-Px,SOD and MDA were de-terminted before and after treatment.Result：In Tongxinluo group,activities of GSH-Px and SOD were sig-nificantly higher after treatment （213.5±53.2mg/L,55.37±10.36u/mL,respectively） than before （153.4± 45.9mg/L,41.35±7.63u/mL,respectively）,MDA level was lower （8.2±0.83nmoL/mL,13.9±0.76nmoL/mL,respectively）, difference was significant（P〈0.01）.After treatment,GSH-Px and SOD （186±38.6mg/L,48.18±7.87u/mL,respectively） the difference was significant（ P〈0.05） between two groups.And com-pared with control group, MDA（9.54±1.07nmoL/mL） difference was significant （P〈0.01）.Conclusion：Tongxinluo can improve the activities of GSH-Px SOD and reduce MDA level.