重症急性胰腺炎并发感染患者的免疫状况研究

Study on the Immune Status of Patients with Infection in Severe Acute Pancreatitis

目的:探讨重症急性胰腺炎并发感染的患者的免疫状况。方法:90例重症急性胰腺炎患者根据是否并发感染将患者分为感染组(49例)和对照组(41例),所有患者均于发病24h内和第28d检测白介素-4、白介素-6、白介素-10、肿瘤坏死因子-α、CD4+T细胞、CD8+T细胞和CD4+/CD8+。结果:在发病24h内,感染组患者的白介素-4、白介素-6、白介素-10、肿瘤坏死因子-α、CD4+/CD8+水平显著高于对照组,差异均具有统计学意义(P<0.05);在发病28d,感染组患者的白介素-4、白介素-6、白介素-10、肿瘤坏死因子-α、CD4+/CD8+水平显著低于对照组,差异均具有统计学意义(P<0.05)。结论:重症急性胰腺炎并发感染患者存在早期过度免疫和晚期免疫抑制的状况,在治疗时应引起重视。

Objective：To explore the immune status of severe acute pancreatitis complicated with infec-tion patients.Method：90 cases of patients with severe acute pancreatitis was complicated by infection.They were divided into infection group （49 cases） and control group （41 cases）, all the patients were on the on-set of 24 hours and 28 days in the detection of interleukin-4, interleukin-6, interleukin-10, tumor necro-sis factor alpha, CD4＋, CD8＋T cells T cells and CD4＋/CD8＋.Result：In the pathogenesis of 24 hours, in-fection patients Interleukin -4, interleukin -6, interleukin -10, tumor necrosis factor alpha, CD4＋/CD8＋level of infection patients was significantly higher than that in the control group, the difference was statistical-ly significant （ P〈0.05）;in the pathogenesis of 28 days, interleukin -4, interleukin -6, interleukin -10, tumor necrosis factor alpha, CD4＋/CD8＋level of infection patients was significantly lower than that of the control group, the difference was statistically significant （ P〈0.05） .Conclusion：Concurrent infection in se-vere acute pancreatitis patients has early excessive immune and advanced immunosuppression status during treatment,It should be paid attention to.