E-cad基因表达与胃癌发生及预后的关系研究

Relation between expression of E-caclherin and progression and prongnesis of gastric cancer

为探讨上皮钙粘附蛋白 (E- cad)基因表达与胃癌发生发展及预后的关系 ,应用免疫组织化学方法检测了 6 5例胃癌、2 5例胃癌前病变患者及 2 0例胃粘膜正常者标本中的 E- cad表达。结果显示 ,胃癌 E- cad异常表达率 (5 3.85 %)显著高于胃癌前病变 (2 4.0 %) ,E- cad表达异常与胃癌的临床分期、分化程度、浸润深度及淋巴结转移密切相关 ,E- cad表达正常胃癌患者的 3年、5年生存率显著高于 E- cad表达异常者 (P<0 .0 5 )。提示 E- cad基因表达与胃癌发生发展密切相关 ,检测 E- cad表达有助于胃癌的早期诊断及转移潜能与预后的判断。

To elucidate the relation between the expression of E-cadherin and progression and prognosis of gastric cancer.The expression of E-cadherin of gastric mucosa was detected in 65 cases of carcinoma,25 cases of dysplasia and 20 cases of healthy control by immunohistochemistry. The abnormal expressive rate of E-cadherin(53.85%) in gastric carcinomas was significantly higher than that in gastric mucosal dysplasia(24.0%),the abnormal expression of E-cadherin was significantly correlated with the gastric cancer stage, poor differentiation,infiltrative tumor growth and lymph nodes metastasis. The three and five-year survival rate of patient with normal E-cadherin expression was significantly higher than that of patients with abnormal expression(P<0.05).The expressions of E-cadherin may be linked with gastric carcinogenesis and progression and prognosis. Determination of E-cadherin will help in predicting tumor metastatic potential and prognosis of patients with gastric cancer.