S100P、GATA3、Ki-67在膀胱尿路上皮癌中的表达及意义

Expression and Significance of S100P,GATA3,and Ki-67 in bladder urothelial carcinoma

目的：探讨S100P、GATA3、Ki-67在膀胱尿路上皮癌中的表达及意义。方法回顾性分析本院收治的2011年1月~2013年12月56例膀胱尿路上皮癌和32例尿路上皮增生患者的临床资料，应用免疫组织化学SP法检测56例膀胱尿路上皮癌和32例尿路上皮增生中S100P、GATA3、Ki-67的表达水平。结果 S100P、GATA3、Ki-67在膀胱尿路上皮癌中呈中至强阳性表达，在低级别非浸润性膀胱尿路上皮癌阳性表达率分别为90.0%、87.5%、85.0%，在高级别浸润性膀胱尿路上皮癌阳性表达率分别为93.8%、87.5%、100.0%；在尿路上皮增生中阳性表达率分别为3.1%、6.2%、6.2%。结论 S100P、GATA3、Ki-67在膀胱尿路上皮癌与尿路上皮增生的鉴别诊断中具有重要价值。

Objective To explore the expression and significance of S100P,GATA3,and Ki-67 in bladder urothelial carcinoma. Methods Clinical data from 56 cases with bladder urothelial carcinoma and 32 cases with urothelial hyper-plasia treated in our hospital from January 2011 to December 2013 were retrospectively analyzed.Expression level of S100P,GATA3,and Ki-67 in 56 bladder urothelial carcinoma cases and 32 urothelial hyperplasia cases were deter-mined by immunohistochemistry SP method. Results S100P,GATA3,and Ki-67 had moderate and strong positive ex-pression in bladder urothelial carcinoma.Positive expression rate of the three indexes in low grade and non-invasive urothelium carcinoma was 90.0%,87.5%,and 85.0% respectively.In the high grade and invasive urothelium carcinoma,it was 93.8%,87.5%,and 100.0% respectively.In the urothelial hyperplasia,positive expression rate of these three deter-mined indexes in urothelial hyperplasia was 3.1%,6.2%,and 6.2% respectively. Conclusion S100P,GATA3,and Ki-67 has important value in the differential diagnosis between bladder urothelial carcinoma and urothelial hyperplasia.