腹膜透析患者微炎症状态与患者营养状况的相关性研究

Correlation study between micro inflammation and nutrition status in patients with peritoneal dialysis

目的：探讨腹膜透析患者微炎症状态与患者营养状况的相关性。方法选择2011年12月~2014年10月入住本院并行腹膜透析的32例尿毒症患者作为研究组，另外选择同期于本院进行体检的健康者28例作为对照组。采用ELISA对表征炎症状态因子（hs-CRP、IL-6及TNF-α）水平进行检测分析。根据血清hs-CRP水平升高与否将研究组分为hs-CRP升高组与hs-CRP正常组，比较两组营养指标（Alb、PA、TF、BUN、Cr及SGA）水平及微炎症状态与患者营养状况的相关性。结果研究组血清hs-CRP、IL-6及TNF-α水平分别为（5.54±1.18） mg/L、（20.85±4.96） pg/ml及（31.83±9.20） pg/ml，均显著高于对照组的（2.00±0.82） mg/L、（10.93±3.27） pg/ml及（15.02±5.66）pg/ml（P〈0.01）；hs-CRP升高组IL-6及TNF-α水平均显著高于hs-CRP正常组，且hs-CRP升高组Alb、PA、TF及SGA水平均显著低于hs-CRP正常组（P〈0.05）；行腹膜透析患者血清微炎症状态相关因子与营养状况相关因子之间呈负相关（P〈0.05）。结论腹膜透析患者均存在一定的微炎症反应，并与患者的营养状况呈负相关。

Objective To evaluate correlation between micro inflammation and nutrition status in patients with peri-toneal dialysis. Methods 32 patients with uremia treated with peritoneal dialysis were recruited from December 2011 to October 2014 in our hospital were selected as study group,28 subjects of healthy people in our hospital at the same time were selected as control group.The serum inflammation factors such hs-CRP,IL-6 and TNF-α were tested by ELISA.According to the serum hs-CRP level,the patients were divided into elevated group and normal group.The nutri-tion indexes such as Alb,PA,TF,BUN,Cr and SGA between two groups were tested and association between micro in-flammation and nutrition status in patients was compared. Results The serum level of hs-CRP,IL-6 and TNF-α in study group was （5.54±1.18） mg/L, （20.85±4.96） pg/ml, （31.83±9.20） pg/ml respectively,significant higher than that in control group [（2.00±0.82） mg/L, （10.93±3.27） pg/ml, （15.02±5.66） pg/ml] respectively （P〈0.01）.The level of IL-6 and TNF-αin hs-CRP elevated group was significantly higher than that in hs-CRP normal group respectively （P〈0.05）.The serum level of Alb,PA,TF and SGA in hs-CRP elevated group was significantly lower than that in hs-CRP normal group respectively（P〈0.05）.The inflammation factor was negative correlate with the nutrition index（P〈0.05）. Conclusion The micro inflammation reaction can be found in patients with peritoneal dialysis which was negative related with nu-trition status.