血同型半胱氨酸水平检测在急性脑梗死中的临床意义

Clinical significance of homocysteine level detection in acute cerebral infarction

目的：探讨血同型半胱氨酸（Hcy）水平检测在急性脑梗死中的临床意义。方法选取本院2011年8月~2014年6月收治的81例急性脑梗死患者为研究对象，根据是否合并颈动脉斑块分为颈动脉斑块组和非颈动脉斑块组，并选取80例健康体检患者作为健康对照组，比较各组间的血Hcy表达水平。结果急性脑梗死组的血Hcy水平为（21.06±4.68）μmol/L，高于健康对照组的（10.11±3.71）μmol/L，差异有统计学意义（P〈0.05）。颈动脉斑块组的血Hcy水平为（22.27±4.58）μmol/L，远高于非颈动脉斑块组的（16.45±2.51）μmol/L，差异有统计学意义（P〈0.05）。结论血Hcy的高水平表达与急性脑梗死的发生及其颈动脉斑块的形成相关，应积极干预以改善预后。

Objective To explore the clinical significance of homocysteine （Hcy） level detection in acute cerebral in-farction （ACI）. Methods 81 patients with ACI admitted into our hospital from August 2011 to June 2014 were selected as research objects.According to whether there was carotid plaque or not,they were divided into carotid plaque group and non-carotid plaque group.Another group of 80 healthy participants from physical examinations were classified into control group.The level of Hcy between the groups was compared. Results The level of Hcy in ACI group was （21.06±4.68） μmol/L,higher than （10.11±3.71） μmol/L in control group,the difference was significant （P〈0.05）.The level of Hcy in the carotid plaque group was （22.27±4.58） μmol/L,higher than （16.45±2.51） μmol/L in non-carotid plaque group,the difference was significant （P〈0.05）. Conclusion High-level expression of Hcy is related with the occurrence of ACI and formation of carotid plaque,which should be positively intervened alming to improve prognosis.