联合应用生长抑素与酚妥拉明治疗肠梗阻的临床体会

Clinical observation on Somatostatin combined with Phentolamine in the treatment of intestinal obstruction

目的探讨生长抑素与酚妥拉明联合治疗肠梗阻的疗效。方法我院2012年5月—2014年6月间收治118例非手术治疗的肠梗阻患者,将患者随机分为治疗组和对照组,每组各59例。2组均给予常规治疗,对照组加用生长抑素治疗;治疗组在对照组的基础上给予酚妥拉明泵注治疗。比较2组患者的治疗效果。结果治疗组59例患者中痊愈52例,占88.1%,好转3例,占5.1%,无效者4例,占6.8%,总有效率为93.2%;对照组59例患者中痊愈42例,占71.2%,好转3例,占5.1%,无效者14例,占23.7%,总有效率为76.3%。治疗组患者的总有效率明显高于对照组,2组比较差异具有统计学意义(P<0.05)。结论生长抑素与酚妥拉明联合应用可提高肠梗阻保守治疗的成功率。

Objective To study the clinical effect of somatostatin combined with phentolamine on patients with intestinal obstruction. Methods Reviewed from May 2012 to June 2014 treated 118 cases of non-surgical treatment of intestinal obstruction in patients with clinical medical records for parenteral nutrition in our hospital. Control group was given Somatostatin on the basis of conventional treatment, while experimental group was given Somatostatin combined with phentolamine. The curative effect was compared between two groups. Results Treatment group of 52 cases cured, 59 patients （88.1%）, improvement in 3 cases （5.1%）, 4 cases were invalid, accounted for 6.8%, total effective rate of 93.2% ;The control group in 42 cases were cured,59 patients （71.2%）,improvement in 3 cases （5.1%）, 14 cases ineffective,accounts for 23.7% ,total effective rate was 76.3%.Compare the therapeutic effect of two groups of patients, the total effective rate of treatment group patients was obviously higher than that of control group total effective rate of statistical results in both groups,statistically significant difference （P〈0.05）. Conclusions Somatostatin and phentolamine combined treatment of intestinal obstruction, and treatment of intestinal obstruction are effective, improve the success rate of conservative treatment.