内镜下黏膜剥离术切除结直肠神经内分泌瘤43例疗效观察

The efficacy of endoscopic submucosal dissection for 43 colorectal neuroendocrine tumor

目的：探讨内镜下黏膜剥离术（endoscopic submucosal dissection，ESD）治疗结直肠神经内分泌瘤的安全性和有效性。方法对重庆医科大学附属第一医院2010年9月至2014年2月43例行ESD治疗的结直肠神经内分泌瘤进行回顾性分析，评估其安全性和有效性。结果43例均在内镜下以ESD术式完整切除，2例（4.65％）术后出现迟发性出血，经内镜止血治疗痊愈；无穿孔发生；4例出现发热，使用抗生素后好转；1例（2.33％）术后1年内镜复查发现复发，行外科手术；其余42例电话或内镜随访未见复发或转移，随访时间6个月～2年（1.07±0.41）年。结论 ESD手术治疗直肠神经内分泌瘤是种简单、安全、有效的方法。

Objective To study the efficacy and safety of endoscopic submucosal dissection （ ESD ） for colorectal neuroendocrine tumor .Methods Clinical data of 43 cases of colorectal neuroendocrine tumor receiving ESD therapy from Sep .2010 to Feb.2014 were retrospectively analyzed , and the safety and efficacy were evalua-ted.Results All the 43 cases received ESD therapy , among whom 2（4.65%）cases developed delayed bleeding and recovered after endoscopic treatment .No perforation was found .4 cases had high fever and recovered after antibiotic treatment.One case（2.33%）of recurrence was found by colonoscopy 1 year later, and underwent sur-gery.The other 42 cases were followed up for 6 months to 2 years, during which no recurrence or metastasis was found.Conclusion ESD is a simple, safe and effective modality for colorectal neuroendocrine tumor .